Protein Details: Voltage-gated sodium channel subunit beta-2

Protein ID

ICDB_Pro_0972

Protein Name

Voltage-gated sodium channel subunit beta-2

Gene Name

Scn2b; Gm183

Organism

Mus musculus (Mouse)

Length

215 amino acids

AlphaFoldDB

AF-Q56A07-F1-model_v4.pdb

Function

Crucial in the assembly; expression; and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

Sequence

MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTAPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

56;135

Disease

Location

Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier

DOI ID

10.1101/gr.2596504; 10.1016/j.cell.2010.12.001

RefSeq

NP_001014761.1